Pepys J
University of London, England.
Am J Ind Med. 1992;21(4):587-93. doi: 10.1002/ajim.4700210414.
The passage of 24 years since the diagnosis of allergic asthma in heavily exposed workers and in a few consumers due to dusty enzyme preparations of Bacillus subtilis compounded with laundry powder makes it possible to review objectively the many problems it raised. It emphasizes the lessons to be learned, relevant to inhalable enzyme products and to other inhalable proteins in general. Occupational allergic respiratory diseases were little studied at the time and the enzyme problems stimulated interest in what has now become a well-established and important field of medicine involving not only protein allergens but low molecular weight chemicals as well.
自大量接触枯草芽孢杆菌含尘酶制剂（与洗衣粉混合）的工人以及少数消费者被诊断出过敏性哮喘以来，已经过去了24年，这使得我们能够客观地审视它所引发的诸多问题。它强调了一些经验教训，这些教训与可吸入酶产品以及一般的其他可吸入蛋白质相关。当时，职业性过敏性呼吸道疾病研究较少，而酶相关问题激发了人们对如今已成为一个成熟且重要医学领域的兴趣，这个领域不仅涉及蛋白质过敏原，还包括低分子量化学物质。
