Acker Michael A
Section of Cardiac Surgery, Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
J Card Fail. 2004 Dec;10(6 Suppl):S220-4. doi: 10.1016/j.cardfail.2004.09.005.
A variety of invasive procedures have been utilized to reduce the burden on the left ventricle in order to slow or reverse the progressive changes of structural remodeling. These include mitral valve repair, left ventricular assist devices, left ventricular chamber reduction surgery, endovascular patchplasty, dynamic cardiomyoplasty, and a variety of prosthetic implants designed to inhibit remodeling either by constraining chamber enlargement or reducing wall stress to inhibit further growth. Resynchronization therapy also may favorably affect remodeling. The potential of these procedures to slow the progression of heart failure needs to be confirmed in prospective studies.
为了减缓或逆转结构重塑的进展性变化，人们已经采用了多种侵入性手术来减轻左心室的负担。这些手术包括二尖瓣修复术、左心室辅助装置、左心室减容手术、血管内补片成形术、动力性心肌成形术以及各种旨在通过限制心室扩大或降低壁应力以抑制进一步生长来抑制重塑的假体植入物。心脏再同步治疗也可能对重塑产生有利影响。这些手术减缓心力衰竭进展的潜力需要在前瞻性研究中得到证实。
