Abetz Linda, Vallow Susan M, Kirsch Jeff, Allen Richard P, Washburn Tinna, Earley Christopher J
Mapi Values Ltd., Macclesfield, Cheshire, UK.
Value Health. 2005 Mar-Apr;8(2):157-67. doi: 10.1111/j.1524-4733.2005.03010.x.
The Restless Legs Syndrome Quality of Life questionnaire (RLSQoL) assesses the impact of RLS on daily life, emotional well-being, social life, and work life. This study investigates its validity and reliability.
The RLSQoL was tested in 85 American adults with primary RLS. Patients were also asked to rate symptom severity with the International Restless Legs Scale (patient-reported version) and report on changes in symptoms over the 2-week period.
The RLSQoL summary scale score (range: 0-100) demonstrated acceptable internal consistency reliability (Cronbach's alpha = 0.92) and test-retest reliability (intraclass correlation coefficient = 0.84). All items indicated acceptable item-convergent validity. The RLSQoL distinguished between groups with mild, moderate, and severe symptoms (F = 52.22, P < 0.0001). It demonstrated preliminary responsiveness to changes in RLS status over 2 weeks (effect size: improvement, 0.25; deterioration, -0.32), indicating moderate scale changes consistent with the small clinical change over this time.
These findings support the conceptual framework of the RLSQoL. It is a valid and reliable measure of the impact of RLS on QoL and is responsive to short-term changes in symptom severity. The RLSQoL appears to be an appropriate tool for trial-based assessments of treatments for RLS.
不安腿综合征生活质量问卷（RLSQoL）评估不安腿综合征对日常生活、情绪健康、社交生活和工作生活的影响。本研究调查其有效性和可靠性。
对85名患有原发性不安腿综合征的美国成年人进行RLSQoL测试。还要求患者用国际不安腿量表（患者报告版）对症状严重程度进行评分，并报告两周内症状的变化。
RLSQoL总结量表得分（范围：0 - 100）显示出可接受的内部一致性可靠性（克朗巴哈系数 = 0.92）和重测可靠性（组内相关系数 = 0.84）。所有项目均显示出可接受的项目收敛效度。RLSQoL能够区分轻度、中度和重度症状组（F = 52.22，P < 0.0001）。它显示出对两周内不安腿综合征状态变化的初步反应性（效应大小：改善，0.25；恶化，-0.32），表明量表变化适中，与这段时间内的小临床变化一致。
这些发现支持RLSQoL的概念框架。它是评估不安腿综合征对生活质量影响的有效且可靠的指标，并且对症状严重程度的短期变化有反应。RLSQoL似乎是用于基于试验的不安腿综合征治疗评估的合适工具。
