噻奈普汀是一种特异性5-羟色胺摄取增强剂，可减少大鼠的乙醇摄入量。
Tianeptine, a specific serotonin uptake enhancer, decreases ethanol intake in rats.
作者信息
Daoust M, Compagnon P, Legrand E, Mocaër E
机构信息
Faculté de Médecine et de Pharmacie de Rouen, Saint Etienne du Rouvray, France.
出版信息
Alcohol Alcohol. 1992 Jan;27(1):15-7.
The effect on ethanol intake of the selective 5-HT uptake enhancer tianeptine was examined in rats and compared with that of fluoxetine, a specific 5-HT uptake inhibitor. Both treatments significantly decreased ethanol intake (54% by tianeptine and 57% by fluoxetine). Fluoxetine also decreased food intake whereas tianeptine did not. Body weight was decreased by 12.5% in fluoxetine-treated rats but was not modified by tianeptine. It is proposed that tianeptine has a specific action on ethanol intake, possibly related to its effect on serotonin function.
在大鼠中研究了选择性5-羟色胺（5-HT）摄取增强剂噻奈普汀对乙醇摄入量的影响，并与特异性5-HT摄取抑制剂氟西汀的作用进行了比较。两种处理均显著降低了乙醇摄入量（噻奈普汀降低54%，氟西汀降低57%）。氟西汀还降低了食物摄入量，而噻奈普汀没有。氟西汀治疗的大鼠体重下降了12.5%，但噻奈普汀对体重没有影响。有人提出，噻奈普汀对乙醇摄入量有特定作用，可能与其对血清素功能的影响有关。
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