Curzon G, Kennett G A, Sarna G S, Whitton P S
Department of Neurochemistry, Institute of Neurology, London.
Br J Psychiatry Suppl. 1992 Feb(15):51-5.
A model of depression based on measurements made after restraining rats for two hours has been developed. The model is associated with elevation in corticosterone, reflects the higher incidence of depression in women, and shows increased post-synaptic 5-HT function with adaptation. The effects of tianeptine and other antidepressants on the model were studied. Chronic pre-treatment with desipramine, sertraline (amine uptake inhibitors), and chlordiazepoxide normalised open field activity after restraint. Single high doses, post-restraint, of 8-OH-DPAT, gepirone (5-HT agonists), and tianeptine normalised open field activity, whereas desipramine, chlordiazepoxide, and diazepam did not. It is of considerable interest that tianeptine decreased the availability of 5-HT to receptors.
基于对大鼠进行两小时束缚后所做测量建立了一种抑郁症模型。该模型与皮质酮升高有关，反映了女性抑郁症发病率较高的情况，并且显示出适应性后突触5-羟色胺（5-HT）功能增强。研究了噻奈普汀和其他抗抑郁药对该模型的影响。用去甲丙咪嗪、舍曲林（胺摄取抑制剂）和氯氮卓进行慢性预处理可使束缚后旷场活动恢复正常。束缚后单次给予高剂量的8-羟基二丙胺基四氢萘（8-OH-DPAT）、吉哌隆（5-HT激动剂）和噻奈普汀可使旷场活动恢复正常，而去甲丙咪嗪、氯氮卓和地西泮则无此作用。值得关注的是，噻奈普汀降低了5-HT与受体的结合能力。
