Bednarska-Makaruk Małgorzata, Rodo Maria, Markuszewski Cezary, Rozenfeld Anna, Swiderska Malgorzata, Habrat Bogusław, Wehr Hanna
Department of Genetics, Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957 Warsaw, Poland.
Alcohol Alcohol. 2005 Jul-Aug;40(4):274-82. doi: 10.1093/alcalc/agh157. Epub 2005 Apr 4.
To investigate the influence of apolipoprotein E (APOE) and angiotensin-converting enzyme (ACE) gene polymorphisms on carotid artery atherosclerosis in alcoholism.
Polymorphism of both genes was identified by DNA analysis in 130 male alcohol-dependent patients. Intima-media thickness (IMT) was measured ultrasonographically.
Multivariate regression analysis showed that of all the known risk factors the greatest impact on carotid atherosclerosis in alcoholics was exerted by age, hypertension, LDL cholesterol and fasting plasma glucose levels. Subjects carrying the APO E epsilon4 allele were more liable to develop atherosclerotic changes in carotid arteries compared with subjects with the epsilon3/3 genotype, which showed statistical significance in patients under 50 years of age. No association was shown between ACE I/D polymorphism and carotid atherosclerosis.
APO E polymorphism can increase the risk of carotid atherosclerosis development in an alcoholic subject. The association of the APO E epsilon4 allele with carotid atherosclerosis was significant in younger patients. Since the elevated carotid IMT is considered to be a good marker of increased risk of generalized atherosclerosis the consequences could involve both cardiac and cerebrovascular events.
研究载脂蛋白E（APOE）和血管紧张素转换酶（ACE）基因多态性对酒精中毒患者颈动脉粥样硬化的影响。
通过DNA分析确定130例男性酒精依赖患者这两种基因的多态性。采用超声测量内膜中层厚度（IMT）。
多因素回归分析显示，在所有已知危险因素中，年龄、高血压、低密度脂蛋白胆固醇和空腹血糖水平对酒精中毒患者颈动脉粥样硬化的影响最大。与携带ε3/3基因型的受试者相比，携带APO E ε4等位基因的受试者更易发生颈动脉粥样硬化改变，这在50岁以下患者中具有统计学意义。未发现ACE I/D多态性与颈动脉粥样硬化之间存在关联。
APO E基因多态性可增加酒精中毒患者发生颈动脉粥样硬化的风险。APO E ε4等位基因与颈动脉粥样硬化的关联在年轻患者中具有显著性。由于颈动脉IMT升高被认为是全身动脉粥样硬化风险增加的良好标志物，其后果可能涉及心脏和脑血管事件。
