Nanda Kumar K S, Ganguly N K, Anand I S, Wahi P L
Department of Cardiology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
APMIS. 1992 Apr;100(4):353-9. doi: 10.1111/j.1699-0463.1992.tb00883.x.
In vitro adherence of Streptococcus pyogenes M type 5 to isolated pharyngeal and buccal epithelial cells was studied in patients with acute recurrent rheumatic fever (n = 21), chronic rheumatic heart disease (n = 33), streptococcal pharyngitis (n = 12), and in normal controls. Patients were investigated at admission and one, six and 12 months later. Streptococci adhered significantly more to the pharyngeal cells of patients with rheumatic fever and rheumatic heart disease than to the pharyngeal cells of controls. Adherence of streptococci to pharyngeal cells of patients with pharyngitis was not different from age-matched controls. The adherence of streptococci to the pharyngeal cells of patients with acute rheumatic fever fell during follow-up but even after one year remained significantly higher than in the control group. These findings suggest that host factor(s) controlling streptococcal adhesion and colonization at the pharyngeal mucosa may be important in the pathogenesis of acute rheumatic fever.
对患有急性复发性风湿热（n = 21）、慢性风湿性心脏病（n = 33）、链球菌性咽炎（n = 12）的患者以及正常对照组，研究了化脓性链球菌M5型在分离出的咽和颊上皮细胞上的体外黏附情况。在入院时以及1个月、6个月和12个月后对患者进行调查。链球菌对风湿热和风湿性心脏病患者的咽细胞的黏附明显多于对对照组咽细胞的黏附。链球菌对咽炎患者咽细胞的黏附与年龄匹配的对照组无差异。急性风湿热患者的链球菌对咽细胞的黏附在随访期间下降，但即使在1年后仍显著高于对照组。这些发现表明，控制链球菌在咽黏膜黏附和定植的宿主因素可能在急性风湿热的发病机制中起重要作用。
