Chepurnov S A, Chepurnova N E, Redkozubova O M, Saakian S A
Usp Fiziol Nauk. 2005 Jan-Mar;36(1):68-84.
This review focuses on the modeling of status epilepticus in animal brain and modern data on the mechanisms of epileptical seizures initiation using the pilocarpine binding with the muscarinic cholinoreceptors (litium pilocarpine model). The character of epileptics seizures in developing brain and adult brain of rats were investigated. The lines of modulation and inhibition epileptics statues by sacricine and intranasal application of neuropeptide thyroliberin in ultra-low doses are demonstrated. The role of the short-term changes (signal regulated kinase signaling cascade, Kv 4.2 potassium channels, hippocampal and cortical spike-wave discharges) and the long-term changes (loss of selective type of interneurons, excitatory circuits by mossy fiber sprouting) that promotion the epileptic state and recurrent seizures in limbic structure are discussed.
本综述聚焦于动物脑内癫痫持续状态的建模以及利用毛果芸香碱与毒蕈碱胆碱能受体结合（锂 - 毛果芸香碱模型）对癫痫发作起始机制的现代数据。研究了大鼠发育中脑和成年脑中癫痫发作的特征。展示了通过骶神经节以及超低剂量鼻内应用神经肽促甲状腺素释放激素对癫痫状态进行调节和抑制的途径。讨论了促进边缘结构癫痫状态和反复癫痫发作的短期变化（信号调节激酶信号级联、Kv 4.2钾通道、海马和皮质棘波发放）以及长期变化（选择性中间神经元类型丧失、苔藓纤维出芽形成兴奋性回路）的作用。
