Onicescu D, Marin A, Mischiu L
Morphol Embryol (Bucur). 1979 Apr-Jun;25(2):153-6.
By means of a histochemical method, the leucine aminopeptidase activity was studied in human normal and leukemic peripheral blood. Before administration of cytostatics the enzymic activity was high in the cytoplasm of blasts and in the nuclei of segmented cells. After therapy the activity of leucine aminopeptidase in blasts decreased, while in polymorphs it became negative in nuclei and positive in their cytoplasm. The non-granular leukocytes and platelets displayed a weak enzymic activity both in normal and malignant blood cells. The erythrocytes were negative.
通过组织化学方法，研究了人正常外周血和白血病外周血中的亮氨酸氨肽酶活性。在给予细胞抑制剂之前，原始细胞的细胞质和分叶细胞的细胞核中的酶活性较高。治疗后，原始细胞中亮氨酸氨肽酶的活性降低，而多形核细胞的细胞核中该活性变为阴性，其细胞质中则变为阳性。无颗粒白细胞和血小板在正常和恶性血细胞中均表现出较弱的酶活性。红细胞呈阴性。
