离子通道研究中的微芯片技术。

Microchip technology in ion-channel research.

作者信息

Sigworth Fred J, Klemic Kathryn G

机构信息

Department of Cellular and Molecular Physiology, Yale University, New Haven, CT 06520-8026, USA.

出版信息

IEEE Trans Nanobioscience. 2005 Mar;4(1):121-7. doi: 10.1109/tnb.2004.842471.

DOI:10.1109/tnb.2004.842471

PMID:15816178

Abstract

The electrical activity of living cells can be monitored in various ways, but for the study of ion channels and the drugs that affect them, the patch-clamp techniques are the most sensitive. Recent developments in microfabricated patch-clamp electrodes are reviewed, and technical challenges for the future are discussed.

摘要

活细胞的电活动可以通过多种方式进行监测，但对于离子通道及其相关药物的研究而言，膜片钳技术最为灵敏。本文综述了微纳加工膜片钳电极的最新进展，并讨论了未来面临的技术挑战。