Kato Yutaro, Tsuyuki Akira, Kikuchi Kiyoshi, Tokuyama Jo, Kurihara Naoto, Kumamoto Yusuke, Fujishiro Yasuo, Ebinuma Hirotoshi
Department of Surgery, Tokyo Denryoku Hospital, 9-2 Shinanomachi, Shinjuku-ku, Tokyo, 160-0016, Japan.
Anticancer Res. 2005 Jan-Feb;25(1B):477-82.
The efficacy of intrahepatic arterial chemotherapy for liver metastasis from biliary tract or pancreatic cancer remains uncertain.
Five patients with bilio-pancreatic liver metastasis underwent continuous hepatic arterial infusion chemotherapy. One treatment course basically consisted of a 14-day infusion period during which continuous infusions of 5-fluorouracil and intermittent bolus injections of cisplatin were given, and a subsequent 14-day intermission. After two consecutive courses, these drugs were administered bi-weekly.
One complete and three partial responses were observed (response rate, 80%). In responders, the responses persisted until or even after the cessation of chemotherapy. The median survival was 15 months after the start of chemotherapy. The longest survivor has been disease-free for 46 months since a liver tumour remaining despite chemotherapy was eradicated by further treatment. Toxicity was acceptable.
5-Fluorouracil and cisplatin-based continuous hepatic arterial infusion chemotherapy may serve as a promising treatment for bilio-pancreatic liver metastasis.
肝内动脉化疗对胆道或胰腺癌肝转移的疗效仍不确定。
5例胆胰肝转移患者接受了持续肝动脉灌注化疗。一个疗程基本包括14天的输注期，在此期间持续输注5-氟尿嘧啶并间歇推注顺铂，随后是14天的间歇期。连续两个疗程后，这些药物每两周给药一次。
观察到1例完全缓解和3例部分缓解（缓解率80%）。在缓解者中，缓解持续到化疗停止甚至化疗停止后。化疗开始后的中位生存期为15个月。最长的幸存者自化疗后残留的肝肿瘤通过进一步治疗被根除以来，已无病生存46个月。毒性是可接受的。
基于5-氟尿嘧啶和顺铂的持续肝动脉灌注化疗可能是治疗胆胰肝转移的一种有前景的方法。
