Mekinová D, Drobná A, Beno I, Bobek P
Výskumný ústav výzivy l'udu, Bratislava.
Cas Lek Cesk. 1992 Feb 21;131(3):73-5.
In 16 obese male patients lipid and apolipoprotein A-I and B in serum were assessed before and after weight reduction. The mean age of the subjects was 34.7 +/- 2.7 years, the mean body weight 124.4 +/- 4.0 kg and the mean BMI 39.1 +/- 1.5 kg/m2. After 10 weeks on a low-energy diet of 2500-6000 kJ/day a decline of body weight was observed on average by 14% of the initial value. The total triacylglycerolaemia declined by 46% (p less than 0.02). The total cholesterol level declined by 12% (ns), HDL-cholesterol by 7% (ns), LDL-cholesterol by 8% (ns). The apo A-I did not change during weight reduction, apo B declined by 13% (ns). The ratio of apo B to apo A-I declined by 12.5% (p less than 0.05). The presented results indicate that after weight reduction of obese patients by a low-energy diet the risk of atherosclerosis declines as the apo B/apo A-I ratio declines.
对16名肥胖男性患者在减重前后的血清脂质、载脂蛋白A-I和载脂蛋白B进行了评估。受试者的平均年龄为34.7±2.7岁，平均体重为124.4±4.0千克，平均体重指数为39.1±1.5千克/平方米。在采用每日2500 - 6000千焦的低能量饮食10周后，观察到体重平均下降了初始值的14%。总甘油三酯血症下降了46%（p<0.02）。总胆固醇水平下降了12%（无统计学意义），高密度脂蛋白胆固醇下降了7%（无统计学意义），低密度脂蛋白胆固醇下降了8%（无统计学意义）。载脂蛋白A-I在减重过程中未发生变化，载脂蛋白B下降了13%（无统计学意义）。载脂蛋白B与载脂蛋白A-I的比值下降了12.5%（p<0.05）。所呈现的结果表明，肥胖患者通过低能量饮食减重后，随着载脂蛋白B/载脂蛋白A-I比值下降，动脉粥样硬化风险降低。
