Audisio Riccardo A, Ramesh Hodigere, Longo Walter E, Zbar Andrew P, Pope Daniel
University of Liverpool, Whiston Hospital, Prescot, L35 5DR, UK.
Oncologist. 2005 Apr;10(4):262-8. doi: 10.1634/theoncologist.10-4-262.
Cancer is a prevalent disease in our aging population; however, few oncologists are familiar with caring for oncogeriatric patients. Surgery is presently the treatment of choice for most solid tumors, but it is frequently delivered in a suboptimal way in this patient subsetting. Undertreatment is often justified with the concern of an unsustainable toxicity, while overtreatment can be related to the lack of knowledge in optimizing preoperative risk assessment. To draw new light on this issue, several surgeons presented their series, providing hard evidence that surgical options can be offered to the elderly with cancer, with only a limited postoperative mortality and morbidity. As it is likely that much of these data suffer from selection bias, we concentrated on Comprehensive Geriatric Assessment (CGA), which can add substantial information on the functional assessment of elderly cancer patients. A validated instrument such as the CGA allows a comparison of series, predicting short-term surgical outcomes more precisely, and offers appropriate information when consenting elderly patients. Preoperative Assessment of Cancer in the Elderly is a prospective international study conceived and launched to outline the fitness of elderly surgical patients with malignant tumors. This paper reports on preliminary results and analysis from the ongoing study.
癌症是我们老龄化人口中的一种常见疾病;然而,很少有肿瘤学家熟悉照顾老年肿瘤患者。目前,手术是大多数实体瘤的首选治疗方法,但在这一患者亚组中,手术的实施方式往往不尽如人意。由于担心毒性无法承受,治疗不足往往被认为是合理的,而过度治疗可能与术前风险评估优化方面的知识欠缺有关。为了重新审视这个问题,几位外科医生展示了他们的病例系列,提供了确凿的证据表明,可以为老年癌症患者提供手术选择,术后死亡率和发病率都有限。由于这些数据很可能存在选择偏倚,我们专注于综合老年评估(CGA),它可以为老年癌症患者的功能评估提供大量信息。像CGA这样经过验证的工具可以对病例系列进行比较,更准确地预测短期手术结果,并在老年患者签署知情同意书时提供适当的信息。老年癌症患者术前评估是一项前瞻性国际研究,旨在概述患有恶性肿瘤的老年手术患者的健康状况。本文报告了这项正在进行的研究的初步结果和分析。