Amar Edouard, Grivel Thierry, Hamidi Karim, Lemaire Antoine, Giuliano François
Service d'Urologie, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
Prog Urol. 2005 Feb;15(1):6-9.
Association between ageing men's progressive falling of circulating androgen levels and ED is not clearly demonstrated. The analysis of all what have been written about this subject clearly proves that an androgenomodulation of erectile function exists. Indeed, the androgens seem to have an action on penile tissue innervation, on the structure and function of penile trabecular smooth muscle, on the penile endothelial function, as well as on the fibroelastic properties of the penile corpus cavernous. The addition of testosterone improves a great number of androgen deficiency in the aging male (ADAM). Recent studies demonstrated that all hypogonadal patients cannot successfully benefit of phosphodiesterase type 5 (PDE5) inhibitors. With these patients, the prescription of testosterone replacement therapy may improve the response of PDE5 inhibitors.
老年男性循环雄激素水平逐渐下降与勃起功能障碍（ED）之间的关联尚未得到明确证实。对关于该主题的所有文献分析清楚地证明，存在对勃起功能的雄激素调节作用。事实上，雄激素似乎对阴茎组织神经支配、阴茎小梁平滑肌的结构和功能、阴茎内皮功能以及阴茎海绵体的纤维弹性特性都有作用。补充睾酮可改善大量老年男性雄激素缺乏（ADAM）的情况。最近的研究表明，并非所有性腺功能减退患者都能成功从5型磷酸二酯酶（PDE5）抑制剂中获益。对于这些患者，睾酮替代疗法的处方可能会改善PDE5抑制剂的疗效。
