杂芳基1,2 - 二酮的合成。
Synthesis of heteroaryl 1,2-diketones.
作者信息
Katritzky Alan R, Zhang Dazhi, Kirichenko Kostyantyn
机构信息
Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville, FL 32611-7200, USA.
出版信息
J Org Chem. 2005 Apr 15;70(8):3271-4. doi: 10.1021/jo0477998.
PMID:15822992
Abstract
Reactions of lithiated heteroaryl- (or aryl-) methylbenzotriazoles 4a-e with heteroaryl (or aryl) esters 5a-f give alpha-benzotriazolyl ketones 6a-n in average yields of 90-95%. Oxidation of ketones 6a-l in aqueous DMSO in the presence of oxygen and sodium bicarbonate gave heteroaryl- (aryl-) 1,2-ethanediones 7a-l in average yields of 60-80%.
摘要
锂化的杂芳基-（或芳基-）甲基苯并三唑4a-e与杂芳基（或芳基）酯5a-f反应，以90 - 95%的平均产率得到α-苯并三唑基酮6a-n。在氧气和碳酸氢钠存在下，于含水二甲基亚砜中氧化酮6a-l，以60 - 80%的平均产率得到杂芳基-（芳基-）1,2 - 乙二酮7a-l。
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