Bhatti H S, Bhushnurmath S, Mahajan R C, Ganguly N K, Sehgal R
Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Exp Parasitol. 1992 May;74(3):283-9. doi: 10.1016/0014-4894(92)90151-y.
Among the wide variety of clinicopathological manifestations of intestinal amebiasis, amebomas occur rarely and their pathogenesis is not well understood. When cholesterol-fed, 2- to 4-week-old guinea pigs were infected intracecally with a virulent, monoaxenic strain of Entamoeba histolytica, gross and histologically characteristic amebomas developed in 85% of the animals by the 3rd day, in 94% by the 9th day, and in 96% by the 12th day postinfection, by which time most of them had died. Amebomas were confirmed by histopathology. Thus, a model of consistent production of amebomas was documented.
在肠道阿米巴病多种多样的临床病理表现中，阿米巴瘤很少见，其发病机制尚不清楚。当给2至4周龄的豚鼠喂食胆固醇后，经盲肠内感染毒力强的单菌培养溶组织内阿米巴菌株，在感染后第3天，85%的动物出现肉眼和组织学特征性的阿米巴瘤；第9天，94%的动物出现；第12天，96%的动物出现，此时大多数动物已经死亡。通过组织病理学证实了阿米巴瘤。因此，记录了一种持续产生阿米巴瘤的模型。
