Chattipakorn Siriporn, Chattipakorn Nipon
Department of Pathology, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
J Med Assoc Thai. 2004 Nov;87(11):1394-401.
Sudden cardiac death is a major health problem in most industrialized countries around the world including Thailand. It is mainly caused by ventricular fibrillation (VF). Currently, defibrillation is the only effective clinical treatment of this fatal arrhythmia. Although defibrillation mechanism has been investigated extensively for many decades, its definite mechanism is still debated. It is known that understanding the basic mechanism of defibrillation is essential to develop better treatment of VF: In the present article, seven hypotheses commonly proposed as the mechanism of ventricular defibrillation are reviewed. Since research in the field of defibrillation mechanism is dynamic, the present review is to update the information to clinicians and basic investigators on the mechanism of defibrillation available to date.
在包括泰国在内的世界上大多数工业化国家，心脏性猝死都是一个重大的健康问题。它主要由心室颤动（VF）引起。目前，除颤是这种致命性心律失常唯一有效的临床治疗方法。尽管数十年来对除颤机制进行了广泛研究，但其确切机制仍存在争议。众所周知，了解除颤的基本机制对于开发更好的室颤治疗方法至关重要：在本文中，对通常作为心室除颤机制提出的七种假说进行了综述。由于除颤机制领域的研究是动态的，本综述旨在向临床医生和基础研究人员更新迄今为止有关除颤机制的可用信息。
