Pereda Ernesto, De la Cruz Dulce M, De Vera Luis, González Julián J
Department of Basic Physics, College of Physics and Mathematics, University of La Laguna, 38205 La Laguna, Tenerife, Spain.
IEEE Trans Biomed Eng. 2005 Apr;52(4):578-83. doi: 10.1109/TBME.2005.844022.
We made use of multivariate nonlinear analysis methods to study the interdependence between the cardiac interval variability and both the respiratory activity and the systolic pressure in rats. The study was carried out in basal conditions and after the application of different drugs affecting the cardiovascular system. The results showed that there are changes both in the extent and in the directionality of such interdependences because of the drugs. The inhibition of the NO and the parasympathetic blockade changed the cardiovascular coordination, with the latter one also modifying the interdependence between the cardiac interval and the respiratory signal. This suggests that the nonlinear approach might be very helpful to explore the interaction between subsystems of the cardiovascular control system.
我们利用多元非线性分析方法研究大鼠心脏间期变异性与呼吸活动及收缩压之间的相互依存关系。该研究在基础条件下以及应用影响心血管系统的不同药物后进行。结果表明，由于药物作用，这种相互依存关系在程度和方向性上均发生了变化。一氧化氮的抑制和副交感神经阻滞改变了心血管协调性，后者还改变了心脏间期与呼吸信号之间的相互依存关系。这表明非线性方法可能对探索心血管控制系统子系统之间的相互作用非常有帮助。
