Daigneault J, Aubin G, Simard F, De Braekeleer M
Department of Human Sciences, Universite du Quebec a Chicoutimi, Canada.
Hum Biol. 1992 Feb;64(1):115-9.
The incidence of cystic fibrosis (CF) in Saguenay-Lac-St.-Jean, a geographically isolated region of Quebec, was estimated to be 1 in 902 during the period 1975-1988. The carrier rate was calculated to be 1 in 15 inhabitants. The high incidence of CF in Saguenay-Lac-St.-Jean is probably the result of a founder effect and genetic drift for one or more mutations. Historical, demographic, and social factors also may have contributed to the high incidence.
在魁北克一个地理上孤立的地区萨格奈-圣让湖地区，1975年至1988年期间囊性纤维化（CF）的发病率估计为902分之一。携带者比率经计算为15分之一居民。萨格奈-圣让湖地区CF的高发病率可能是一个或多个突变的奠基者效应和遗传漂变的结果。历史、人口统计学和社会因素也可能导致了高发病率。
