[骨髓基质细胞与骨缺损修复]
[Marrow stromal cells and repair of bone defect].
作者信息
Peng Songlin, Fang Huang, Luo Yongxiang
机构信息
Department of Orthopaedics, Tongji Hospital, Tongji Medical College of Huazhong Science and Technology University, Wuhan Hubei 430030, PR China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2005 Mar 15;19(3):245-8.
OBJECTIVE
To review researches on the relation between marrow stromal cells (MSCs) and repair of bone defect.
METHODS
The latest original literatures about marrow stromal cells and their use in the treatment of bone defect were extensively reviewed.
RESULTS
Marrow stromal cells were induced to osteoblasts under proper conditions and showed the potential of bone formation in vivo. The methods of bone tissue engineering using MSCs as seed cells and gene therapy using MSCs as target cells were both useful in the repair of bone defect.
CONCLUSION
MSCs have a promising future in the repair of bone defect.
目的
综述骨髓基质细胞（MSCs）与骨缺损修复关系的研究。
方法
广泛查阅有关骨髓基质细胞及其在骨缺损治疗中应用的最新原始文献。
结果
在适当条件下，骨髓基质细胞可诱导分化为成骨细胞，并在体内显示出骨形成潜力。以MSCs作为种子细胞的骨组织工程方法以及以MSCs作为靶细胞的基因治疗方法在骨缺损修复中均有应用价值。
结论
骨髓基质细胞在骨缺损修复方面具有广阔前景。
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