Martini A K, Blimke B
Sektion Handchirurgie, Stiftung Orthopädische Universitätsklinik Heidelberg.
Helv Chir Acta. 1992 Jan;58(4):431-7.
The purpose of the present study was to determine whether tendons contain intrinsic cells capable of repair. To accomplish this, rabbit flexor tendons were exposed microsurgically, cut through, resutured and transferred as free transplant into the knee-joint. Immobilisation of the knee-joint will cause progressive formation of adhesions permitting neovascularisation of the transplant. Both is not observed when sutured flexor tendons were put in a knee articulation with full range of joint motion. Transmission electron micrography revealed up to 8 weeks after implantation vital cells and incidences of collagen neosynthesis independently whether adhesions existed or not. Histologically intrinsic repair was confirmed in mobile transplants and mainly initiated by cells of the visceral synovial sheet which form an anatomic-surgical unity with the tendon. In conclusion the importance of the synovial fluid for the tendon nutrition is underlined by the fact that an intrinsic healing of flexor tendon is possible without formation of adhesions.
本研究的目的是确定肌腱是否含有能够进行修复的固有细胞。为实现这一目的，通过显微外科手术暴露兔的屈肌腱，将其切断、缝合，然后作为游离移植物转移至膝关节。膝关节固定会导致粘连逐渐形成，从而使移植物新生血管化。当缝合后的屈肌腱置于关节可全范围活动的膝关节时，则不会出现上述两种情况。透射电子显微镜检查显示，植入后长达8周，无论是否存在粘连，均可发现有活力的细胞以及胶原新生现象。组织学检查证实，可活动的移植物存在固有修复，且主要由与肌腱形成解剖 - 手术统一体的脏层滑膜片的细胞启动。总之，滑膜液对肌腱营养的重要性体现在以下事实：屈肌腱能够进行固有愈合且不形成粘连。
