Bioequivalency studies on tablet formulation of tetroxoprim and sulphadiazine.

The paper describes a comparative bioavailability study on two tablet formulations containing 100 mg of tetroxoprim and 250 mg of sulphadiazine. The comparison was based on the estimated pharmacokinetic parameters from time--serum concentration profiles obtained following the administration of the tablets to 12 healthy volunteers. Statistical analysis performed on the parameters showed that the differences are statistically insignificant and the formulations are bioequivalent.