Alkaysi H N, Salem M A, Gharaibeh A M, Gharaibeh K I, Badwan A A
Faculty of Pharmacy, Jordan University of Science and Technology, Irbid.
J Clin Pharm Ther. 1992 Apr;17(2):97-9. doi: 10.1111/j.1365-2710.1992.tb01274.x.
The paper describes a comparative bioavailability study on two tablet formulations containing 100 mg of tetroxoprim and 250 mg of sulphadiazine. The comparison was based on the estimated pharmacokinetic parameters from time--serum concentration profiles obtained following the administration of the tablets to 12 healthy volunteers. Statistical analysis performed on the parameters showed that the differences are statistically insignificant and the formulations are bioequivalent.
该论文描述了一项关于两种片剂制剂的比较生物利用度研究，这两种制剂含有100毫克甲氧苄啶和250毫克磺胺嘧啶。比较基于对12名健康志愿者服用片剂后获得的血清浓度随时间变化曲线所估算的药代动力学参数。对这些参数进行的统计分析表明，差异无统计学意义，两种制剂具有生物等效性。
