Waris Eero, Ashammakhi Nureddin, Kelly Christopher P, Andrus Lee, Waris Timo, Jackson Ian T
Institute for Craniofacial and Reconstructive Surgery, Province Hospital, Southfield, MI, USA.
J Pediatr Orthop. 2005 May-Jun;25(3):342-5. doi: 10.1097/01.bpo.0000150845.02162.f7.
A self-reinforced bioabsorbable poly-L-lactide/polyglycolide (SR-PLGA) 80/20 screw 2.0 mm in diameter was implanted transphyseally across the distal growth plate of the right femur in 24 immature rabbits. Radiologic evaluation revealed a mean shortening of 3.1 mm at 3 weeks, 11.1 mm at 6 weeks, 9.3 mm at 24 weeks, 9.0 mm at 48 weeks, and 12.6 mm at 72 weeks compared with the intact contralateral femur. In 13 control rabbits, drilling without screw placement did not cause any statistically significant femoral shortening. Therefore, the transphyseal SR-PLGA 80/20 screw caused growth retardation for 6 weeks postoperatively, after which the normal growth tendency was recovered until the growth plate was closed. The duration of temporary growth retardation correlated with that of strength retention of the SR-PLGA 80/20 copolymer. These findings suggest that SR-PLGA 80/20 screws can be applied in transphyseal bone fixation. The use of bioabsorbable screws for temporary epiphysiodesis seems attractive but requires further study.
将直径2.0毫米的自增强生物可吸收聚L-丙交酯/聚乙交酯（SR-PLGA）80/20螺钉经骨骺植入24只未成熟兔右股骨的远端生长板。放射学评估显示，与完整的对侧股骨相比，3周时平均缩短3.1毫米，6周时缩短11.1毫米，24周时缩短9.3毫米，48周时缩短9.0毫米，72周时缩短12.6毫米。在13只对照兔中，钻孔但不放置螺钉未导致任何具有统计学意义的股骨缩短。因此，经骨骺的SR-PLGA 80/20螺钉在术后6周导致生长迟缓，此后直到生长板闭合恢复正常生长趋势。暂时生长迟缓的持续时间与SR-PLGA 80/20共聚物的强度保持时间相关。这些发现表明，SR-PLGA 80/20螺钉可用于经骨骺骨固定。使用生物可吸收螺钉进行临时骨骺阻滞似乎很有吸引力，但需要进一步研究。
