来自半规则刺冠海星的新型细胞毒性硫酸化皂苷。

New cytotoxic sulfated saponins from the starfish Certonardoa semiregularis.

作者信息

Wang Weihong, Jang Hyojin, Hong Jongki, Lee Chong-Ok, Bae Song-Ja, Shin Sook, Jung Jee H

机构信息

College of Pharmacy, Pusan National University, Busan 609-735, Korea.

出版信息

Arch Pharm Res. 2005 Mar;28(3):285-9. doi: 10.1007/BF02977793.

DOI:10.1007/BF02977793

PMID:15832814

Abstract

Two new sulfated saponins designated as certonardosides P2 and I3 (1 and 2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds 1 and 2 were tested for cytotoxicity against five human tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15), and compound 1 displayed significant cytotoxicity against the SK-MEL-2 skin cancer cell.

摘要

从半规则瘤海星甲醇提取物的卤虫活性部分中分离出两种新的硫酸化皂苷，命名为瘤海皂苷P2和I3（1和2）。通过光谱分析确定了其结构。测试了化合物1和2对五种人类肿瘤细胞系（A549、SK-OV-3、SK-MEL-2、XF498和HCT15）的细胞毒性，化合物1对SK-MEL-2皮肤癌细胞显示出显著的细胞毒性。