Roed Hanne, Frederiksen Jette, Langkilde Annika, Sørensen Torben Lykke, Lauritzen Martin, Sellebjerg Finn
The MS Clinic, Department of Neurology, University of Copenhagen, Glostrup Hospital, DK-2600 Glostrup, Denmark.
J Neuroimmunol. 2005 May;162(1-2):165-72. doi: 10.1016/j.jneuroim.2005.02.002.
We examined untreated 60 patients with acute monosymptomatic optic neuritis (ON). Patients examined early after onset showed increased expression of HLA-DR and CD45R0 on CD4 and CD8 T cells. Expression of HLA-DR on CD4 T cells was higher in patients without IgG oligoclonal bands. Expression of HLA-DR on CD4 and CD8 T cells correlated negatively with measures of disease activity and positively with measures of good visual function, and expression of CD45R0 on CD4 T cells correlated negatively with measures of disease activity. We hypothesize that HLA-DR expression may characterize a protective T-cell subset in ON.
我们检查了60例未经治疗的急性单症状性视神经炎（ON）患者。发病后早期接受检查的患者，其CD4和CD8 T细胞上的HLA-DR和CD45R0表达增加。无IgG寡克隆带的患者，其CD4 T细胞上HLA-DR的表达更高。CD4和CD8 T细胞上HLA-DR的表达与疾病活动度指标呈负相关，与良好视觉功能指标呈正相关，而CD4 T细胞上CD45R0的表达与疾病活动度指标呈负相关。我们推测，HLA-DR表达可能是ON中一种保护性T细胞亚群的特征。
