Saillenfait A M, Gallissot F, Sabate J P, Morel G
Institut National de Recherche et de Sécurité, Avenue de Bourgogne, B.P. No. 27, 54501 Vandoeuvre, France.
Food Chem Toxicol. 2005 Jul;43(7):1055-63. doi: 10.1016/j.fct.2005.02.008.
The developmental toxicity of two trimethylbenzene isomers, mesitylene (1,3,5-trimethylbenzene) and pseudocumene (1,2,4-trimethylbenzene) was studied in Sprague-Dawley rats following inhalation exposure. Pregnant rats were exposed whole body to vapours of mesitylene (0, 100, 300, 600, and 1200 ppm) or pseudocumene (0, 100, 300, 600, and 900 ppm), 6h/day, on gestational days (GD) 6 through 20. Significant decrease in maternal body weight gain and food consumption was observed at concentrations of 300 ppm mesitylene, 600 ppm pseudocumene, or greater. Fetal toxicity, expressed as significant reduction in fetal body weight, occurred at 600 and 1200 ppm mesitylene, and at 600 and 900 ppm pseudocumene. There was no evidence of embryolethal or teratogenic effects following inhalation exposure to either of these chemicals. In summary, the no-observed-adverse-effect-level (NOAEL) for maternal toxicity was 100 ppm for mesitylene and 300 ppm for pseudocumene, and the NOAEL for developmental toxicity was 300 ppm for mesitylene and pseudocumene.
在吸入暴露后，对两种三甲苯异构体，即均三甲苯（1,3,5 - 三甲苯）和偏三甲苯（1,2,4 - 三甲苯）在斯普拉格 - 道利大鼠中的发育毒性进行了研究。妊娠大鼠在妊娠第6天至第20天期间，每天6小时全身暴露于均三甲苯（0、100、300、600和1200 ppm）或偏三甲苯（0、100、300、600和900 ppm）的蒸汽中。在均三甲苯浓度为300 ppm、偏三甲苯浓度为600 ppm及更高浓度时，观察到母体体重增加和食物摄入量显著下降。胎儿毒性表现为胎儿体重显著降低，在均三甲苯浓度为600和1200 ppm以及偏三甲苯浓度为600和900 ppm时出现。吸入暴露于这两种化学物质中的任何一种后，均未发现胚胎致死或致畸作用。总之，母体毒性的未观察到有害作用水平（NOAEL），均三甲苯为100 ppm，偏三甲苯为300 ppm；发育毒性的NOAEL，均三甲苯和偏三甲苯均为300 ppm。
