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C/EBPdelta and C/EBPgamma bind the CCAAT-box in the human beta-globin promoter and modulate the activity of the CACC-box binding protein, EKLF.

作者信息

Gordon Christopher T, Fox Vanessa J, Najdovska Suzana, Perkins Andrew C

机构信息

Institute for Molecular Bioscience, University of Queensland, St. Lucia, 4072, QLD, Australia.

出版信息

Biochim Biophys Acta. 2005 May 25;1729(1):74-80. doi: 10.1016/j.bbaexp.2005.03.004. Epub 2005 Mar 31.

DOI:10.1016/j.bbaexp.2005.03.004
PMID:15833715
Abstract

Developmental- and tissue-specific expression of globin genes is mediated by a few key elements within the proximal promoter of each gene. DNA-binding assays previously identified NF-Y, GATA-1, C/EBPbeta and C/EBPgamma as candidate regulators of beta-globin transcription via the CCAAT-box, a promoter element situated between CACC- and TATA-boxes. We have identified C/EBPdelta as an additional beta-globin CCAAT-box binding protein. In reporter assays, we show that C/EBPdelta can co-operate with EKLF, a CACC-box binding protein, to activate the beta-globin promoter, whereas C/EBPgamma inhibits the transcriptional activity of EKLF in this assay.

摘要

相似文献

1
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2
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