Wong Stephen N, Sollano Jose D, Chan Melchor M, Carpio Ramon E, Tady Celina S, Ismael Albert E, Judan-Ruiz Estelita A, Ang Victorio N, Go Johnny T, Lim Victoriano Y, Perez Jesus Y, Alvarez Sol Z
Section of Gastroenterology, University of Santo Tomas, España, Manila, The Philippines.
J Gastroenterol Hepatol. 2005 Apr;20(4):628-32. doi: 10.1111/j.1440-1746.2005.03719.x.
The declining global prevalence of peptic ulcer disease (PUD) might be because of the decreasing prevalence of Helicobacter pylori (Hp) infection. The aims of the present study were to determine the prevalence of PUD during a 7-year period and to investigate its relationship with the prevalence of Hp infection during the same period.
All upper gastrointestinal endoscopies carried out at Santo Tomas Hospital in Manila from January 1996 to December 2002 were evaluated. Endoscopies reporting gastric ulcers (GU) and duodenal ulcers (DU) with Hp status were analyzed.
A total of 15 341 endoscopies were evaluated. Overall, 2600 (16.95%) GU and 1575 (10.27%) DU were identified. There was a decreasing trend in the prevalence of GU (P < 0.0001) and DU (P < 0.0001) during the study period. Overall PUD prevalence declined from 35.87% in 1996 to 18.80% in 2002. This decline was seen for both GU and DU (20.05 vs 14.34%, and 15.83 vs 7.02%, respectively). The prevalence of Hp infection decreased significantly from 1996 to 2002 for both GU and DU (68.13 vs 33.48%, P < 0.0001; and 76.67 vs 36.50%, P < 0.0001, respectively). The decrease in Hp prevalence was significantly related to the decrease in ulcer prevalence (r = 0.97, P = 0.0004 for GU; r = 0.89, P = 0.0079 for DU; and r = 0.92, P = 0.0035 for all PUD). The prevalence of bleeding secondary to PUD remained stable during the 7-year period (P = 0.87).
During the 7-year period, there was a significant decline in the prevalence of PUD. This decline in PUD prevalence was associated with a corresponding decrease in Hp prevalence.
全球消化性溃疡疾病（PUD）患病率的下降可能是由于幽门螺杆菌（Hp）感染率的降低。本研究的目的是确定7年间PUD的患病率，并调查其与同期Hp感染率的关系。
对1996年1月至2002年12月在马尼拉圣托马斯医院进行的所有上消化道内镜检查进行评估。分析报告有Hp状态的胃溃疡（GU）和十二指肠溃疡（DU）的内镜检查。
共评估了15341例内镜检查。总体而言，发现2600例（16.95%）GU和1575例（10.27%）DU。在研究期间，GU（P<0.0001）和DU（P<0.0001）的患病率呈下降趋势。总体PUD患病率从1996年的35.87%下降到2002年的18.80%。GU和DU均出现这种下降（分别为20.05%对14.34%，以及15.83%对7.02%）。1996年至2002年，GU和DU的Hp感染率均显著下降（分别为68.13%对33.48%，P<0.0001；以及76.67%对36.50%，P<0.0001）。Hp患病率的下降与溃疡患病率的下降显著相关（GU的r=0.97，P=0.0004；DU的r=0.89，P=0.0079；所有PUD的r=0.92，P=0.0035）。7年间，PUD继发出血的患病率保持稳定（P=0.87）。
在7年期间，PUD患病率显著下降。PUD患病率的下降与Hp患病率的相应降低有关。
