Snf5肿瘤抑制因子将染色质重塑、检查点控制和染色体稳定性联系起来。
Snf5 tumor suppressor couples chromatin remodeling, checkpoint control, and chromosomal stability.
作者信息
Imbalzano Anthony N, Jones Stephen N
机构信息
University of Massachusetts Medical School, Department of Cell Biology, Worcester, Massachusetts 01655, USA.
出版信息
Cancer Cell. 2005 Apr;7(4):294-5. doi: 10.1016/j.ccr.2005.04.001.
SNF5 is a core subunit of the SWI/SNF chromatin-remodeling complex. Mammalian SNF5 is essential for normal cell viability, and loss or mutation of the human SNF gene is the molecular basis for familial malignant rhabdoid tumorigenesis. Previous studies have suggested that SNF5 suppresses cancer by signaling through the p16Ink4a and retinoblastoma tumor suppressors to negatively regulate cell cycle progression from G0/G1 into S phase. A recent paper in Genes & Development (Vries et al., 2005) reports that human SNF5 also signals via the p16INK4a-Rb-E2F pathway to regulate chromosomal stability, suggesting a new function for this chromatin remodeling protein in tumor suppression.
SNF5是SWI/SNF染色质重塑复合物的一个核心亚基。哺乳动物的SNF5对正常细胞的生存能力至关重要，人类SNF基因的缺失或突变是家族性恶性横纹肌样瘤发生的分子基础。先前的研究表明，SNF5通过p16Ink4a和视网膜母细胞瘤肿瘤抑制因子发出信号，以负向调节细胞周期从G0/G1期进入S期，从而抑制癌症。《基因与发育》杂志最近发表的一篇论文（弗里斯等人，2005年）报道，人类SNF5还通过p16INK4a-Rb-E2F途径发出信号来调节染色体稳定性，这表明这种染色质重塑蛋白在肿瘤抑制方面具有新功能。
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