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[预防热性惊厥的新进展]

[New aspects in prevention of febrile convulsions].

作者信息

Siemes H

机构信息

Kinderklinik des Rittberg-Krankenhauses.

出版信息

Klin Padiatr. 1992 Mar-Apr;204(2):67-71. doi: 10.1055/s-2007-1025325.

Abstract

In general, febrile convulsions have a good prognosis. The risk of death or neurologic and mental handicap is low. Though the risk of epilepsy is increased, there is no evidence that anticonvulsant treatment can prevent occurrence of later epilepsy. The aim of anticonvulsive prophylaxis is reduction of the rate of recurrences of febrile convulsions. Recent results point against the assumption that these can be prevented by long-term anticonvulsive treatment with phenobarbital or valproate. An alternative for longterm prophylaxis is intermittent short-term rectal application of diazepam suggested for children with a hightened risk of recurrences. Long-term prophylaxis with phenobarbital should only be considered in a small number of selective children.

摘要

一般来说,热性惊厥预后良好。死亡、神经和精神障碍的风险较低。虽然癫痫风险增加,但没有证据表明抗惊厥治疗可预防后期癫痫的发生。抗惊厥预防的目的是降低热性惊厥复发率。近期结果与下述假设相悖,即苯巴比妥或丙戊酸盐长期抗惊厥治疗可预防热性惊厥复发。对于复发风险较高的儿童,间歇性短期直肠应用地西泮是长期预防的一种替代方法。仅在少数有选择性的儿童中才应考虑苯巴比妥长期预防。

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