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[恶性肿瘤发展过程中的免疫反应动力学]

[Immune response dynamics during malignant tumor development].

作者信息

Stepanova N V

出版信息

Biofizika. 1979 Sep-Oct;24(5):897-902.

PMID:158393
Abstract

Several mathematical models for the development of immune reaction during cancer diseases were plotted. The models describe both stimulation of the immune system by the tumor and its suppression. Non-specific inhibition was considered which resulted from glucose deficiency accompanying the development of a malignant tumor. The inhibiting effect of antitumour antibodies on toxic influence of limphocytes-killers was taken into account. The qualitative and quantitative study of the models showed the limits for the description of real interactions between tumour and organism by the mechanisms stated.

摘要

绘制了几种癌症疾病中免疫反应发展的数学模型。这些模型描述了肿瘤对免疫系统的刺激及其抑制作用。考虑了恶性肿瘤发展过程中伴随的葡萄糖缺乏导致的非特异性抑制。还考虑了抗肿瘤抗体对淋巴细胞杀伤细胞毒性影响的抑制作用。对这些模型的定性和定量研究表明,所述机制在描述肿瘤与机体之间实际相互作用方面存在局限性。

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