Zhang Xin, Wu Ling-ying, Li Xiao-jiang, Li Hong-jun, Zhang Rong, Liu Li-ying
Department of Gynecologic Oncology, Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing.
Zhonghua Fu Chan Ke Za Zhi. 2005 Mar;40(3):178-82.
To investigate serum CA(125) levels and the value of serum CA(125) in differential diagnosis of benign pelvic mass.
We retrospectively analyzed 492 patients with benign pelvic mass, including 237 cases of benign ovarian tumor and 255 other benign gynecological diseases. Sixty cases of ovarian epithelial cancer were randomly chosen as control group.
The median of serum CA(125) in patients with pelvic tuberculosis, uterine adenomyosis, ovarian endometriosis and ovarian fibroma were all higher than the cut-off level of CA(125) (35 kU/L), being 465.0, 88.9, 59.0 and 44.5 kU/L, respectively. Those of ovarian epithelial cancer patients were significantly higher than in benign pelvic mass (P < 0.01). The highest value of CA(125) among all the benign cases was 1281.0 kU/L, which was seen in a case of ovarian thecoma. The highest median value was 465.0 kU/L, detected in a patient with pelvic tuberculosis.
Serum CA(125) levels in some benign pelvic mass are higher than the cut-off level of CA(125), such as pelvic tuberculosis, uterine adenomyosis, ovarian fibroma and ovarian endometriosis. The medians of serum CA(125) in benign pelvic mass are much lower than in ovarian epithelial cancer. Serum CA(125) is of significance in the differential diagnosis between hysteromyoma and uterine adenomyosis.
探讨血清CA(125)水平及其在盆腔良性肿块鉴别诊断中的价值。
回顾性分析492例盆腔良性肿块患者，其中包括237例卵巢良性肿瘤和255例其他妇科良性疾病。随机选取60例卵巢上皮癌患者作为对照组。
盆腔结核、子宫腺肌病、卵巢子宫内膜异位症和卵巢纤维瘤患者血清CA(125)的中位数均高于CA(125)的临界值（35 kU/L），分别为465.0、88.9、59.0和44.5 kU/L。卵巢上皮癌患者的血清CA(125)中位数显著高于盆腔良性肿块患者（P < 0.01）。所有良性病例中CA(125)的最高值为1281.0 kU/L，见于1例卵巢卵泡膜细胞瘤患者。最高中位数为465.0 kU/L，见于1例盆腔结核患者。
一些盆腔良性肿块患者的血清CA(125)水平高于CA(125)的临界值，如盆腔结核、子宫腺肌病、卵巢纤维瘤和卵巢子宫内膜异位症。盆腔良性肿块患者血清CA(125)的中位数远低于卵巢上皮癌患者。血清CA(125)在子宫肌瘤与子宫腺肌病的鉴别诊断中具有重要意义。
