Gottifredi Vanesa, Prives Carol
Fundación Instituto Leloir, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires 1405, Argentina.
Semin Cell Dev Biol. 2005 Jun;16(3):355-68. doi: 10.1016/j.semcdb.2005.02.011.
Accumulation of unrepaired DNA lesions is the biggest threat to genomic stability. DNA damage checkpoints create windows of time that allow the cell to repair assaults on DNA in each phase of the cell cycle. When DNA lesions arise in S phase, however, the checkpoint machinery must work to coordinate DNA replication and repair processes. In fact some upstream components of the DNA damage checkpoint play parallel roles in maintaining the continuity of DNA replication and signaling to downstream components.
未修复的DNA损伤积累是对基因组稳定性的最大威胁。DNA损伤检查点创造了时间窗口，使细胞能够在细胞周期的每个阶段修复对DNA的攻击。然而，当DNA损伤在S期出现时，检查点机制必须协同工作以协调DNA复制和修复过程。事实上，DNA损伤检查点的一些上游组件在维持DNA复制的连续性以及向下游组件发出信号方面发挥着并行作用。
