Truin G J, van 't Hof M A
Department of Preventive and Restorative Dentistry/117, Radboud University, Nijmegen Medical Center, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands.
J Dent Res. 2005 May;84(5):418-21. doi: 10.1177/154405910508400504.
The question has been raised whether low-caries children regularly using fluoride toothpaste will benefit from the professional application of additional fluoride gel. To investigate the caries-reducing effect of semi-annually-applied neutral 1% sodium fluoride gel, we carried out a double-blind randomized controlled clinical trial (n = 594) in a child population, initially aged 9.5-11.5 years, with baseline caries experience of D3MFS = 0 (decayed, missing, and filled tooth surfaces of permanent teeth). The mean number of tooth surfaces saved from caries development by fluoride gel application after 4 years was 0.2 D3MFS (SE = 0.17). The preventive fraction (PF) showed a mean relative effect of professionally applied fluoride gel of 18%. The cariostatic effect of the fluoride gel on pits and fissures would have been influenced by the sealant strategy in the study. Professionally applied fluoride gel showed no statistically significant effect on mean D3MFS score in low-caries 9.5- to 11.5-year-olds.
经常使用含氟牙膏的低龋儿童是否会从专业应用额外的氟凝胶中获益，这一问题已经被提出。为了研究每半年应用一次中性1%氟化钠凝胶的防龋效果，我们在一群初始年龄为9.5至11.5岁、恒牙龋经验基线为D3MFS = 0（恒牙龋、失、补牙面）的儿童中开展了一项双盲随机对照临床试验（n = 594）。4年后，通过应用氟凝胶预防龋齿发展的牙面平均数量为0.2 D3MFS（标准误 = 0.17）。预防率（PF）显示专业应用氟凝胶的平均相对效果为18%。在该研究中，氟凝胶对窝沟的防龋效果会受到窝沟封闭策略的影响。专业应用氟凝胶对9.5至11.5岁低龋儿童的平均D3MFS评分没有统计学上的显著影响。
