Lee Y Y, Lee N S, Cho Y M, Moon M K, Jung H S, Park Y J, Park H J, Youn B S, Lee H K, Park K S, Shin H D
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Diabet Med. 2005 May;22(5):569-75. doi: 10.1111/j.1464-5491.2005.01460.x.
To investigate any association between Type 2 diabetes mellitus and two single nucleotide polymorphisms (SNPs) in the adiponectin gene, T45G and G276T, in the Korean population.
We genotyped 427 non-diabetic controls and 493 Type 2 diabetic patients for SNPs T45G and G276T of adiponectin gene, measured plasma adiponectin concentrations, and examined clinical parameters in Koreans.
There were no statistically significant differences in allele frequencies of SNPs 45 and 276 comparing control with Type 2 diabetic subjects (T frequency 68.3% vs. 71.6%, P=0.13 for SNP45, G frequency 72.2% vs. 68.9%, P=0.12 for SNP276). The genotype distributions of these SNPs had no association with the risk of Type 2 diabetes and metabolic parameters of insulin resistance. Plasma levels of adiponectin were not statistically different according to T45G and G276T either, in both control and Type 2 diabetic subjects.
The T45G and G276T of the adiponectin gene may not be an important determinant of Type 2 diabetes or insulin resistance in Korean subjects.
在韩国人群中研究2型糖尿病与脂联素基因中的两个单核苷酸多态性（SNP），即T45G和G276T之间的任何关联。
我们对427名非糖尿病对照者和493名2型糖尿病患者进行脂联素基因SNP T45G和G276T的基因分型，测量血浆脂联素浓度，并检查韩国人的临床参数。
将对照者与2型糖尿病受试者相比，SNP 45和276的等位基因频率没有统计学上的显著差异（SNP45的T频率为68.3%对71.6%，P = 0.13；SNP276的G频率为72.2%对68.9%，P = 0.12）。这些SNP的基因型分布与2型糖尿病风险和胰岛素抵抗的代谢参数无关。在对照者和2型糖尿病受试者中，根据T45G和G276T的血浆脂联素水平也没有统计学差异。
脂联素基因的T45G和G276T可能不是韩国受试者中2型糖尿病或胰岛素抵抗的重要决定因素。
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