慢性丙型肝炎患者中非酒精性脂肪性肝炎存在的相关因素。

Factors associated with the presence of nonalcoholic steatohepatitis in patients with chronic hepatitis C.

作者信息

Solis-Herruzo José A, Pérez-Carreras Mercedes, Rivas Eloy, Fernández-Vázquez Inmaculada, Garfia Cristina, Bernardos Esther, Castellano Gregorio, Colina Francisco

机构信息

Departments of Gastroenterology and Pathology, Hospital Universitario Doce de Octubre, Madrid, Spain.

出版信息

Am J Gastroenterol. 2005 May;100(5):1091-8. doi: 10.1111/j.1572-0241.2005.41059.x.

DOI:10.1111/j.1572-0241.2005.41059.x

PMID:15842583

Abstract

OBJECTIVES

The aim of this study was to identify factors associated with the presence of nonalcoholic steatohepatitis (NASH) in patients with chronic hepatitis C (CHC).

METHODS

We studied 98 patients with CHC [47 with NASH (group HCV/NASH), 51 without NASH (group HCV)] and 85 with NASH not infected with hepatitis C virus (HCV) (group NASH). We determined factors associated with the presence of NASH in patients with hepatitis C.

RESULTS

Group HCV/NASH patients resembled those with NASH. Body mass index (BMI) was higher in group HCV/NASH than in group HCV, but was similar to group NASH. Most HCV/NASH patients had risk factors for NASH. In patients infected with HCV, NASH and NASH-related lesions were independently associated with BMI, while steatosis score was associated with HCV genotype 3 and BMI. Fibrosis stage was independently associated with steatosis, necroinflammatory activity index, and NASH lesions.

CONCLUSION

While HCV genotype 3 infection and BMI are associated with the presence of steatosis in CHC, BMI is the only factor independently associated with the presence of NASH in these patients. We suggest that overweight-related factors might induce NASH in CHC patients.

摘要

目的

本研究旨在确定慢性丙型肝炎（CHC）患者中非酒精性脂肪性肝炎（NASH）存在的相关因素。

方法

我们研究了98例CHC患者[47例患有NASH（HCV/NASH组），51例未患NASH（HCV组）]以及85例未感染丙型肝炎病毒（HCV）的NASH患者（NASH组）。我们确定了丙型肝炎患者中与NASH存在相关的因素。

结果

HCV/NASH组患者与NASH患者相似。HCV/NASH组的体重指数（BMI）高于HCV组，但与NASH组相似。大多数HCV/NASH患者具有NASH的危险因素。在感染HCV的患者中，NASH和NASH相关病变与BMI独立相关，而脂肪变性评分与HCV 3型和BMI相关。纤维化阶段与脂肪变性、坏死性炎症活动指数和NASH病变独立相关。