Tan Seang Lin, Child Timothy J, Cheung Anthony P, Fluker Margo R, Yuzpe Albert, Casper Robert, Leung Peter, Cadesky Kenneth, Davis Victoria J
Department of Obstetrics and Gynecology, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada.
J Assist Reprod Genet. 2005 Feb;22(2):81-8. doi: 10.1007/s10815-005-1497-1.
To compare the efficiency and efficacy of two starting doses of recombinant FSH (follitropin-beta, Puregon) in women undergoing IVF treatment.
This prospective, randomized, double-blind, multicentric (N = 6) study included 192 women undergoing IVF using the long protocol of GnRH agonist who received either 100 IU or 200 IU of r-FSH per day. Gonadotropin dose adjustment was allowed after day 4 of stimulation.
The average (SD) number of oocytes retrieved was 10.9 (5.4) and 12.2 (5.6) in the 100 IU and 200 IU group respectively (p = 0.067). The total doses of Puregon administered were 1887 IU and 2559 IU in the 100 IU and 200 IU group respectively. The number of transferable embryos, and the rates of pregnancies, cancelled cycles, miscarriages and adverse events including OHSS were comparable between the two groups.
Women undergoing IVF have similar outcomes whether recombinant FSH is commenced in a dose of 100 IU or 200 IU for the first 4 days of stimulation.
比较两种起始剂量的重组促卵泡素（重组促卵泡素β，果纳芬）在接受体外受精（IVF）治疗的女性中的有效性和功效。
这项前瞻性、随机、双盲、多中心（N = 6）研究纳入了192名采用GnRH激动剂长方案进行IVF治疗的女性，她们每天接受100 IU或200 IU的重组促卵泡素。刺激第4天后允许调整促性腺激素剂量。
100 IU组和200 IU组平均（标准差）取卵数分别为10.9（5.4）和12.2（5.6）（p = 0.067）。100 IU组和200 IU组果纳芬的总给药剂量分别为1887 IU和2559 IU。两组间可移植胚胎数、妊娠率、取消周期率、流产率以及包括卵巢过度刺激综合征（OHSS）在内的不良事件发生率相当。
在刺激的前4天，接受IVF治疗的女性无论起始剂量为100 IU还是200 IU的重组促卵泡素，结局相似。
