通过提高脑内γ-氨基丁酸浓度来拮抗苯环利定引起的小鼠多动。
Antagonism of phencyclidine-induced hyperactivity in mice by elevated brain GABA concentrations.
作者信息
Seiler N, Grauffel C
机构信息
Marion Merrell Dow Research Institute, Strasbourg, France.
出版信息
Pharmacol Biochem Behav. 1992 Mar;41(3):603-6. doi: 10.1016/0091-3057(92)90379-t.
Vigabatrin and (S)-4-allenylGABA (MDL 72483), two anticonvulsant GABA-T inhibitors, partially antagonize phencyclidine (PCP)-induced hyperactivity in mice at doses that do not affect spontaneous motor activity. The PCP antagonism is related to whole-brain GABA concentrations. The results indicate the potential use of GABA-T inhibitors in the therapy of PCP intoxications and perhaps also in the treatment of certain forms of endogenous psychoses.
两种抗惊厥性γ-氨基丁酸转氨酶（GABA-T）抑制剂，即氨己烯酸和（S）-4-烯丙基-GABA（MDL 72483），在不影响小鼠自发运动活性的剂量下，可部分拮抗苯环利定（PCP）诱导的小鼠多动。PCP拮抗作用与全脑γ-氨基丁酸浓度有关。结果表明，GABA-T抑制剂在PCP中毒治疗中以及可能在某些形式的内源性精神病治疗中具有潜在用途。
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