Madeja U D
Abteilung Innere Medizin, Schering AG, Berlin.
Acta Histochem Suppl. 1992;42:25-31.
The development of fluctuations in disability are a main problem of the levodopa long-term treatment in Parkinson's disease. The early combination of low doses of levodopa with a dopamine agonist as lisuride improves the symptoms of Parkinson's disease as much as a monotherapy but prevents the development of fluctuations in disability and dyskinesias at the same time.
残疾波动的出现是帕金森病左旋多巴长期治疗的一个主要问题。早期将低剂量左旋多巴与多巴胺激动剂如利苏瑞ide联合使用，与单一疗法一样能改善帕金森病症状，但同时可预防残疾波动和异动症的出现。
