Wkly Epidemiol Rec. 2005 Apr 8;80(14):126-32.
The main goals of the meeting--to provide guidelines for describing the major genetic groups of rubella virus and to establish uniform genetic analysis protocols--were achieved. Guidelines for describing the genotypes as an operational taxonomic group consisted of the designation of reference viruses and reference sequences for 7 genotypes of rubella viruses representing 2 clades, and designation of an additional 3 provisional genotypes. Provisional genotype status was given either because reference viruses were not yet available and/or because there was uncharacterized complexity within the genetic group. Uniform analysis protocols recommended the comparison of unknown viral sequences with the complete set of designated reference viruses, and recommended a minimum acceptable sequence window which produced phylogenetic results with high confidence values. A list of literature references about rubella virus phylogeny and molecular epidemiology is available from the WHO Internet site for this report. As additional understanding of the genetic characteristics of wild-type rubella viruses is achieved, updates to the recommended nomenclature will be made and published in the Weekly Epidemiological Record.
会议的主要目标——为描述风疹病毒的主要基因群提供指导方针并建立统一的基因分析方案——已经实现。将基因型描述为一个操作分类单位的指导方针包括指定代表两个进化枝的7种风疹病毒基因型的参考病毒和参考序列，以及指定另外3种临时基因型。给予临时基因型地位的原因要么是尚未获得参考病毒，和/或因为基因群内存在未表征的复杂性。统一分析方案建议将未知病毒序列与指定参考病毒的完整集合进行比较，并建议使用产生具有高置信度值的系统发育结果的最小可接受序列窗口。关于风疹病毒系统发育和分子流行病学的文献参考列表可从世卫组织本报告的互联网网站获取。随着对野生型风疹病毒基因特征的进一步了解，将对推荐的命名法进行更新并发表在《疫情周报》上。
