DNA完整性的维持与神经元变性。

Preservation of DNA integrity and neuronal degeneration.

作者信息

Francisconi Simona, Codenotti Mara, Ferrari-Toninelli Giulia, Uberti Daniela, Memo Maurizio

机构信息

Department of Biomedical Sciences and Biotechnologies, University of Brescia, Medical School, Italy.

出版信息

Brain Res Brain Res Rev. 2005 Apr;48(2):347-51. doi: 10.1016/j.brainresrev.2004.12.023.

DOI:10.1016/j.brainresrev.2004.12.023

PMID:15850673

Abstract

The mismatch repair system (MMR) is an important member of the DNA checkpoint, that includes a number of protein deputed to control genomic stability through cell cycle arrest, DNA repair, and apoptosis. Here we summarize some recent data from our and other groups underlining the contribution to neurodegeneration of MSH2, perhaps the most relevant component of the MMR system. These data suggest that this protein participates not only in the cancer prevention machinery for the body but also in neurodegenerative processes.

摘要

错配修复系统（MMR）是DNA检查点的重要成员，它包括许多负责通过细胞周期停滞、DNA修复和细胞凋亡来控制基因组稳定性的蛋白质。在这里，我们总结了来自我们团队和其他团队的一些最新数据，这些数据强调了MMR系统中可能最相关的组成部分MSH2对神经退行性变的作用。这些数据表明，这种蛋白质不仅参与身体的癌症预防机制，还参与神经退行性变过程。