移动的信息：mRNA的细胞内定位

Moving messages: the intracellular localization of mRNAs.

作者信息

St Johnston Daniel

机构信息

The Gurdon Institute and The Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

出版信息

Nat Rev Mol Cell Biol. 2005 May;6(5):363-75. doi: 10.1038/nrm1643.

DOI:10.1038/nrm1643

PMID:15852043

Abstract

mRNA localization is a common mechanism for targeting proteins to regions of the cell where they are required. It has an essential role in localizing cytoplasmic determinants, controlling the direction of protein secretion and allowing the local control of protein synthesis in neurons. New methods for in vivo labelling have revealed that several mRNAs are transported by motor proteins, but how most mRNAs are coupled to these proteins remains obscure.

摘要

信使核糖核酸（mRNA）定位是一种将蛋白质靶向运输到细胞内所需区域的常见机制。它在定位细胞质决定因子、控制蛋白质分泌方向以及实现神经元中蛋白质合成的局部调控方面发挥着重要作用。体内标记的新方法表明，几种mRNA是由驱动蛋白运输的，但大多数mRNA如何与这些蛋白质结合仍不清楚。