Ivanov S, Ivanov S, Khadzhiolov N
Akush Ginekol (Sofiia). 2005;44(1):11-3.
A retrospective study of 450 ovarian biopsy results were examined for the period of 1998 till 2004 to evaluate the accuracy of frozen section diagnosis. In addition to this we performed a review of the literature for all previous studies in this field in order to study the accuracy rates of the different clinics throughout the world. The histhopathological results of the frozen section diagnosis were equal with the diagnosis of the paraffin blocks in 90%. The sensitivity rates for benign, malignant and borderline tumours, were 96%, 84% and 60% respectively. We had 10 patients (2,1%) false-positive results (overdiagnosed) and 26 (5,2%) false-negative results (underdiagnosed) in frozen section examinations. Frozen section examination of mucinous tumours showed hogher underdiagnosis--18%. The review of the literature showed that there is no significant difference in accuracy rates of frozen section diagnosis for benign and malignant ovarian tumours in relation with time. We found low accuracy rates for borderline tumours which was similar with most of the foreign publications. However the accuracy of the frozen section diagnosis is bettering with the time. As a result of this we conclude that the accuracy rates of the frozen section diagnosis for evaluation of the malignant and benign tumours is quite enough for correct diagnosis. Since accuracy rates for borderline ovarian tumours are low we have to take care and attention of improvement in this field.
对1998年至2004年期间450例卵巢活检结果进行回顾性研究,以评估冰冻切片诊断的准确性。除此之外,我们还对该领域之前所有的研究进行了文献综述,以便研究世界各地不同诊所的准确率。冰冻切片诊断的组织病理学结果与石蜡块诊断结果的相符率为90%。良性、恶性和交界性肿瘤的敏感度分别为96%、84%和60%。在冰冻切片检查中,我们有10例患者(2.1%)出现假阳性结果(过度诊断),26例(5.2%)出现假阴性结果(诊断不足)。黏液性肿瘤的冰冻切片检查显示诊断不足率较高——为18%。文献综述表明,冰冻切片诊断良性和恶性卵巢肿瘤的准确率在时间上没有显著差异。我们发现交界性肿瘤的准确率较低,这与大多数国外出版物的情况相似。然而,冰冻切片诊断的准确性随着时间的推移在提高。因此我们得出结论,冰冻切片诊断评估恶性和良性肿瘤的准确率足以进行正确诊断。由于卵巢交界性肿瘤的准确率较低,我们必须关注并致力于该领域的改进。