Cahana Alex, Mavrocordatos Philippe, Geurts Jos W M, Groen Gerbrand J
Department of Anesthesiology, Pharmacology and Surgical Intensive Care, Geneva University Hospital, Geneva, Switzerland.
Expert Rev Neurother. 2004 May;4(3):479-90. doi: 10.1586/14737175.4.3.479.
Chronic low back pain is the leading cause of disability in the industrialized world. Medical and surgical treatments remain costly despite limited efficacy. The field of 'interventional pain' has grown enormously and evidence-based practice guidelines are systematically developed. In this article, the vast, complex and contradictory literature regarding the treatment of chronic low back pain is reviewed. Interventional pain literature suggests that there is moderate evidence (small randomized, nonrandomized, single group or matched-case controlled studies) for medial branch neurotomy and limited evidence (nonexperimental one or more center studies) for intradiscal treatments in mechanical low back pain. There is moderate evidence for the use of transforaminal epidural steroid injections, lumbar percutaneous adhesiolysis and spinal endoscopy for painful lumbar radiculopathy, and spinal cord stimulation and intrathecal pumps mostly after spinal surgery. In reality, there is no gold standard for the treatment of chronic low back pain, but these results appear promising.
慢性下腰痛是工业化国家致残的主要原因。尽管疗效有限,但药物和手术治疗成本依然高昂。“介入性疼痛治疗”领域发展迅速,循证实践指南也在系统地制定。本文回顾了关于慢性下腰痛治疗的大量、复杂且相互矛盾的文献。介入性疼痛治疗文献表明,对于机械性下腰痛,有中等证据(小型随机、非随机、单组或配对病例对照研究)支持内侧支神经切断术,而对于椎间盘内治疗仅有有限证据(非实验性的单中心或多中心研究)。对于疼痛性腰椎神经根病,使用经椎间孔硬膜外类固醇注射、腰椎经皮粘连松解术和脊柱内镜有中等证据,而脊髓刺激和鞘内泵治疗大多用于脊柱手术后,且有一定证据支持。实际上,慢性下腰痛的治疗尚无金标准,但这些结果看起来很有前景。