Fan Jia, Tang Zhao-you, Wu Zhi-quan, Zhou Jian, Zhou Xin-da, Ma Zeng-chen, Qin Lun-xiu, Qiu Shuang-jian, Yu Yao, Huang Cheng
Institute of Liver Cancer, Department of Hepatic Surgery, Zhongshan Hospital of Fudan University, Shanghai 200032, China.
Zhonghua Wai Ke Za Zhi. 2005 Apr 1;43(7):433-5.
To evaluate the effects of portal vein microscopic and macroscopic tumor thrombi on post-operation patients with hepatocellular carcinoma (HCC).
Three thousand three hundred and forty eight HCC patients were retrospectively reviewed, which were divided into no portal vein tumor thrombi (PVTT), microscopic PVTT and macroscopic PVTT groups according to the pathology, effects of portal vein microscopic and macroscopic tumor thrombi on post-operation patients's survival were studied by univariate analysis and overall survival was evaluated in each group.
Hazard ratio (HR) of portal vein microscopic tumor thrombi and macroscopic tumor thrombi was 1.421 and 3.136 respectively; The overall 1-, 3-, 5- and 10-year cumulative survival rate was 85.97%, 62.78%, 49.88% and 35.42% respectively, and mean time for survival was 59.7 months in group without PVTT, while 74.42%, 51.66%, 39.25% and 27.28% respectively and mean time for survival 39.1 months in group with microscopic PVTT, 52.59%, 25.97%, 20.42% and 11.33% respectively and mean time for survival 13.5 months in group with macroscopic PVTT.
PVTT was an important prognostic factor for survival in post-operation patients with HCC while macroscopic PVTT was more danger than microscopic PVTT. The period of microscopic PVTT was the landmark affecting post-operation survival.
评估门静脉微观和宏观肿瘤血栓对肝细胞癌（HCC）术后患者的影响。
回顾性分析3348例HCC患者，根据病理将其分为无门静脉肿瘤血栓（PVTT）组、微观PVTT组和宏观PVTT组，采用单因素分析研究门静脉微观和宏观肿瘤血栓对术后患者生存的影响，并评估每组的总生存期。
门静脉微观肿瘤血栓和宏观肿瘤血栓的风险比（HR）分别为1.421和3.136；无PVTT组的1年、3年、5年和10年总累积生存率分别为85.97%、62.78%、49.88%和35.42%，平均生存时间为59.7个月，微观PVTT组分别为74.42%、51.66%、39.25%和27.28%，平均生存时间为39.1个月，宏观PVTT组分别为52.59%、25.97%、20.42%和11.33%，平均生存时间为13.5个月。
PVTT是HCC术后患者生存的重要预后因素，宏观PVTT比微观PVTT更危险。微观PVTT期是影响术后生存的标志。
