Louis Elan D, Applegate LaKeisha, Factor-Litvak Pam, Parides Michael K
G.H. Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Neuroepidemiology. 2005;25(1):42-7. doi: 10.1159/000085312. Epub 2005 Apr 25.
Motor signs in essential tremor (ET) are varied. Patients may have limb tremors, including postural, kinetic (e.g. writing, pouring), and rest tremors, head tremor, voice tremor, or chin tremor. Factor analysis allows one to determine whether these signs fall into a smaller number of discrete domains. Such an analysis has not been performed on a group of ET cases. ET cases (n = 168) were recruited from the Neurological Institute of New York and a videotaped examination was performed. A factor analysis was performed on 17 motor items. Four distinct factors emerged, explaining 68.7% of the total variance. These were factor I (action tremor in the dominant arm), factor II (action tremor in the nondominant arm), factor III (tremor at rest) and factor IV (chin tremor, head tremor, and voice tremor). The demonstration of these four factors will be of potential use for pathological and genetic studies as well as interventional studies, as will be discussed.
特发性震颤（ET）的运动体征多种多样。患者可能出现肢体震颤，包括姿势性震颤、动作性震颤（如书写、倒液体时）和静止性震颤、头部震颤、声音震颤或下颌震颤。因子分析可以确定这些体征是否可归为较少数量的离散域。尚未对一组ET病例进行过此类分析。从纽约神经学研究所招募了168例ET病例，并进行了录像检查。对17项运动项目进行了因子分析。出现了四个不同的因子，解释了总方差的68.7%。它们分别是因子I（优势手臂动作性震颤）、因子II（非优势手臂动作性震颤）、因子III（静止性震颤）和因子IV（下颌震颤、头部震颤和声音震颤）。正如将要讨论的，这四个因子的证明对于病理学和遗传学研究以及干预性研究可能具有潜在用途。
