首发精神分裂症的精神病理学与弓形虫抗体
Psychopathology in first-episode schizophrenia and antibodies to Toxoplasma gondii.
作者信息
Bachmann S, Schröder J, Bottmer C, Torrey E F, Yolken R H
机构信息
Section of Geriatric Psychiatry, Department of Psychiatry, University of Heidelberg, DE-69115 Heidelberg, Germany.
出版信息
Psychopathology. 2005 Mar-Apr;38(2):87-90. doi: 10.1159/000085349. Epub 2005 Apr 22.
OBJECTIVE
Environmental factors such as infectious agents may contribute to the psychopathology and aetiology of schizophrenia. Toxoplasma gondii (TG) is a candidate infectious agent as it is known to replicate within the human central nervous system and to alter behaviour in experimental animals.
METHOD
The relationship between antibodies to TG and psychopathological symptoms was examined in 34 first-episode patients with schizophrenia.
RESULTS
Results of regression analyses revealed that symptoms on admission, predictors of outcome, age and family history of psychiatric disease influenced the levels of antibodies to TG.
CONCLUSIONS
These results indicate that TG infections may play a role in the clinical manifestation of psychopathology in a subgroup of patients with schizophrenia.
目的
诸如传染源等环境因素可能对精神分裂症的精神病理学及病因学产生影响。刚地弓形虫（TG）是一种潜在的传染源，因为已知其可在人类中枢神经系统内复制，并改变实验动物的行为。
方法
对34例首发精神分裂症患者检测了其针对TG的抗体与精神病理症状之间的关系。
结果
回归分析结果显示，入院时的症状、预后预测因素、年龄及精神疾病家族史会影响针对TG的抗体水平。
结论
这些结果表明，TG感染可能在一部分精神分裂症患者精神病理学的临床表现中起作用。
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