Deng Yanshen, Nicholson Russell A
Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Planta Med. 2005 Apr;71(4):364-5. doi: 10.1055/s-2005-864105.
The natural product electron transport inhibitor surangin B was examined for its ability to inhibit in vitro mycelial growth and spore germination in several species of fungi. As an inhibitor of mycelial growth, surangin B showed strongest activity against Rhizoctonia solani (IC50 = 3.8 microM) and Botrytis cinerea (IC50 = 11.2 microM). Inhibitory effects were less pronounced in Alternaria dauci, Fusarium oxysporum and Penicillium sp. (IC50 values > 30 microM) and absent in Trichoderma harzianum. Surangin B reduced the level of spore germination in Fusarium oxysporum (IC50 = 2.3 microM) and Botrytis cinerea (IC50 = 1.4 microM), although Alternaria dauci was considerably more tolerant of this coumarin (IC50 = 500 microM). Our results indicate that surangin B may have potential as an antifungal agent.
对天然产物电子传递抑制剂苏兰金B抑制几种真菌体外菌丝体生长和孢子萌发的能力进行了研究。作为菌丝体生长抑制剂，苏兰金B对茄丝核菌（IC50 = 3.8微摩尔）和灰葡萄孢菌（IC50 = 11.2微摩尔）表现出最强的活性。在胡萝卜链格孢菌、尖孢镰刀菌和青霉属中，抑制作用不太明显（IC50值> 30微摩尔），而在哈茨木霉中则没有抑制作用。苏兰金B降低了尖孢镰刀菌（IC50 = 2.3微摩尔）和灰葡萄孢菌（IC50 = 1.4微摩尔）的孢子萌发水平，尽管胡萝卜链格孢菌对这种香豆素的耐受性要强得多（IC50 = 500微摩尔）。我们的结果表明，苏兰金B可能具有作为抗真菌剂的潜力。
