Simforoosh Nasser, Basiri Abbas, Tabibi Ali, Shakhssalim Nasser
Department of Urology & Renal Transplantation, Urology Nephrology Research Center, Shahid Labbafinejad Hospital and Shahid Beheshti University of Medical Science, Tehran, Iran.
Exp Clin Transplant. 2004 Dec;2(2):249-53.
This study aimed to evaluate donor and graft outcome in kidney transplantations from laparoscopic donor nephrectomies.
From June 2000 to June 2004, 341 laparoscopic donor nephrectomies were performed. Demographics and hospital records were reviewed. Mean ages of donors and recipients were 27.59+/-4.80 years (range, 20-56 years) and 35.36+/-14.85 years (range, 3-75 years).
Nephrectomy was left sided in 96.2%. Mean follow-up was 13.32+/-35.98 months. Mean warm ischemia time was 8.17 minutes (range, 2.5-19 minutes). Mean operative time was 260.34 minutes. Median serum creatinine levels (mg/dL) of the recipients were 1.30, 1.45, and 1.20 at day 7, and at 1 and 12 months. One-year graft survival was 92.7%, 94.6%, and 92.6% in the laparoscopic donor nephrectomy groups with warm ischemia times of less than 6, 6-10, and more than 10 minutes (P=NS). Conversion to open surgery occurred in 2.1% of donors, and reoperation was performed in 3.8% of laparoscopic donor nephrectomies. Blood transfusion was required in 7.1% of donors. Ureteral complications were observed in 2.1% of recipients. Vascular control was performed using medium-large clips instead of endo GIA, and the kidney was extracted via a suprapubic approach using the hand instead of an ENDOCATCH bag; hence, $600 was saved in each nephrectomy. No vascular accident occurred from pedicular vessels.
Laparoscopic donor nephrectomy can be performed with a less-expensive setup (to be expanded in developing countries) without jeopardizing results. Because warm ischemic time in our study did not affect graft outcome significantly, there appears to be no need to rush harvesting the kidney to achieve a better quality kidney. Vascular control using nonautomatic clips instead of more costly endo GIA and hand extraction of the kidney is safe, practical, and economical.
本研究旨在评估腹腔镜供肾切除术的供体和移植肾结局。
2000年6月至2004年6月期间,共进行了341例腹腔镜供肾切除术。回顾了人口统计学资料和医院记录。供体和受体的平均年龄分别为27.59±4.80岁(范围20 - 56岁)和35.36±14.85岁(范围3 - 75岁)。
96.2%的肾切除术为左侧。平均随访时间为13.32±35.98个月。平均热缺血时间为8.17分钟(范围2.5 - 19分钟)。平均手术时间为260.34分钟。受体术后第7天、1个月和12个月时血清肌酐水平(mg/dL)的中位数分别为1.30、1.45和1.20。热缺血时间小于6分钟、6 - 10分钟和大于10分钟的腹腔镜供肾切除术组,1年移植肾存活率分别为92.7%、94.6%和92.6%(P = 无显著性差异)。2.1%的供体转为开放手术,3.8%的腹腔镜供肾切除术进行了再次手术。7.1%的供体需要输血。2.1%的受体出现输尿管并发症。血管控制采用中型至大型血管夹而非Endo GIA,肾脏通过耻骨上途径徒手取出而非使用ENDOCATCH袋;因此,每例肾切除术节省了600美元。未发生来自肾蒂血管的血管意外。
腹腔镜供肾切除术可以在成本较低的条件下进行(在发展中国家可推广)且不影响手术效果。由于本研究中的热缺血时间对移植肾结局无显著影响,似乎无需匆忙摘取肾脏以获取质量更好的肾脏。使用非自动血管夹而非更昂贵的Endo GIA进行血管控制以及徒手取出肾脏是安全、实用且经济的。