在氟烷敏感型和氟烷非敏感型猪的治疗过程中进行的体内肌肉31P核磁共振波谱分析。

In vivo muscle 31P nuclear magnetic resonance spectroscopy during treatment of halothane-sensitive and halothane-nonsensitive pigs.

作者信息

Geers R, Decanniere C, Villé H, Van Hecke P, Goedseels V, Vanstapel F, Bosschaerts L, De Ley J, Zhang W, Janssens S

机构信息

Laboratory for Agricultural Buildings Research, Catholic University Leuven, Belgium.

出版信息

Am J Vet Res. 1992 Apr;53(4):613-6.

PMID:1586038

Abstract

In vivo muscle 31P nuclear magnetic resonance spectroscopy was performed on 10 female pigs originating from a homozygous halothane-sensitive line and on 10 female pigs from a homozygous halothane-nonsensitive line. The mean concentration of phosphocreatine in the biceps femoris muscle of the anesthetized pigs decreased to 86% of the initial value after 11 minutes of halothane exposure (3%, oxygen flow 3 L/min). After the next 5.6 minutes, phosphocreatine concentration reached a minimal value of 52%, followed by a mean recovery to 76% of the initial value during the ensuing 11 minutes. Response was not observed in anesthetized homozygous halothane-nonsensitive pigs. Thus, a decrease to 86% of the initial value of phosphocreatine was 100% predictive for homozygous halothane-sensitive pigs with body weight ranging from 10 to 18 kg.

摘要

对来自纯合氟烷敏感品系的10头雌性猪和来自纯合氟烷不敏感品系的10头雌性猪进行了活体肌肉31P核磁共振波谱分析。在氟烷暴露11分钟后（3%，氧气流量3 L/min），麻醉猪股二头肌中的磷酸肌酸平均浓度降至初始值的86%。在接下来的5.6分钟后，磷酸肌酸浓度达到最小值52%，随后在接下来的11分钟内平均恢复到初始值的76%。在麻醉的纯合氟烷不敏感猪中未观察到反应。因此，磷酸肌酸初始值降至86%对体重在10至18 kg的纯合氟烷敏感猪具有100%的预测性。